Long‐term evolution of white and gray matter structural properties in migraine
Differences in clinical evolution are linked to distinct patterns of structural changes, suggesting a heterogeneous impact of disease evolution on brain structure. Patients with CM who improved to EM showed no significant GM differences while those with longitudinally stable diagnoses showed cortical thickness maladaptation in pain processing-related regions and adaptation in other regions associated with migraine. Patients who improved from CM to EM showed an opposite longitudinal trend in large WM regions compared to stable patients, possibly as an adaptation to a distinct entity.
Authors
- David García‐Azorín (ORCID: https://orcid.org/0000-0002-3132-1064)
- Ángel Luis Guerrero Peral (ORCID: https://orcid.org/0000-0001-7493-6002)
- Rodrigo de Luis-Garcı́a (ORCID: https://orcid.org/0000-0001-5023-6490)
- Santiago Aja‐Fernández (ORCID: https://orcid.org/0000-0002-5337-5071)
- Álvaro Planchuelo‐Gómez (ORCID: https://orcid.org/0000-0002-2188-4197)
- Carmen Martín‐Martín (ORCID: https://orcid.org/0000-0002-1679-2060)
Institutions
- Universidad de Valladolid (ES)
- Hospital Clínico Universitario de Valladolid (ES)
- Hospital Universitario Río Hortega (ES)
Publication Details
- Journal
- Headache The Journal of Head and Face Pain
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1111/head.14949
- Citations
- 1
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- European Commission
- Ministerio de Ciencia e Innovación
- Ministerio de Ciencia y Tecnología
- Junta de Castilla y León
- Agencia Estatal de Investigación
- European Social Fund