<scp>TNF</scp> ‐α‐Induced Paneth Cell Dysfunction and Gut Bacterial Translocation: Implications for the Mechanism of Enterogenic Infection in Sepsis
In a recent Cell Host & Microbe paper, Wallaeys et al. demonstrate that TNF signaling critically regulates Paneth cell dysfunction and bacterial sepsis pathogenesis, and highlights a critical localized mechanism in the gut, making a substantial contribution to our understanding of TNF's role in gut-derived sepsis pathogenesis.
Authors
- Yiming Lu (ORCID: https://orcid.org/0000-0003-3497-1860)
- Yonghong Zhou (ORCID: https://orcid.org/0000-0002-1242-1764)
- Yingying Li (ORCID: https://orcid.org/0000-0003-3914-3490)
Institutions
- Shanghai University (CN)
Publication Details
- Journal
- The FASEB Journal
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1096/fj.202500530rr
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China