Impact of tracer uptake rate on quantification accuracy of myocardial blood flow in PET: A simulation study
This study showed that an increase in the tracer uptake rate (K<sub>1</sub>) corresponded to improved accuracy and precision in MBF quantification, whereas lower tracer uptake resulted in higher noise in dynamic PET and poorer parameter estimates. Utilizing denoising techniques or DL approaches can mitigate noise-induced bias in PET parametric imaging.
Authors
- Yazdan Salimi (ORCID: https://orcid.org/0000-0002-1233-9576)
- Habib Zaidi (ORCID: https://orcid.org/0000-0001-7559-5297)
- René Nkoulou (ORCID: https://orcid.org/0000-0001-6192-0351)
- Lijun Lu (ORCID: https://orcid.org/0000-0002-7001-4892)
- Hossein Arabi (ORCID: https://orcid.org/0000-0001-6526-0960)
- Xiaotong Hong (ORCID: https://orcid.org/0000-0002-6079-8638)
- Amirhossein Sanaat (ORCID: https://orcid.org/0000-0001-8437-2060)
Institutions
- Obuda University (HU)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- University of Southern Denmark (DK)
- University Hospital of Geneva (CH)
- Innova (Hungary) (HU)
- Southern Medical University (CN)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1002/mp.17871
- Citations
- 2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Natural Science Foundation of China
- China Scholarship Council