<i>Plasmodium falciparum</i> isolates: <i>ex vivo</i> drug response
Clinical isolates from coastal Ghana remain susceptible to artemisinin derivatives in commonly used ACTs in Ghana. However, we observed lower susceptibility to the ACT partner drugs lumefantrine and amodiaquine, suggesting the emergence of drug-tolerance phenotypes. Consistent surveillance of drug phenotype-genotype is needed to support ACT efficacy in Ghana.
Authors
- Alfred Amambua‐Ngwa (ORCID: https://orcid.org/0000-0003-4478-3601)
- Collins M. Morang’a (ORCID: https://orcid.org/0000-0002-6988-150X)
- Gordon A. Awandare (ORCID: https://orcid.org/0000-0002-8793-3641)
- Enock K. Amoako (ORCID: https://orcid.org/0009-0005-6035-9220)
- Yaw Aniweh (ORCID: https://orcid.org/0000-0002-8415-2727)
- Lucas Naam-Kayagre Amenga-Etego (ORCID: https://orcid.org/0000-0003-4468-0506)
- Jersley D. Chirawurah (ORCID: https://orcid.org/0000-0002-4861-0938)
- Samirah Saiid (ORCID: https://orcid.org/0009-0008-0778-6276)
- Michael Essien Sakyi
- Edem Adika (ORCID: https://orcid.org/0000-0003-4655-9515)
- Daniel Dosoo
- Ahmed Osumanu
Institutions
- University of Ghana (GH)
- MRC Unit the Gambia (GM)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1093/jac/dkaf129
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Bill and Melinda Gates Foundation
- European Commission