Mechanism of action of total saponin Achyranthes in treating knee osteoarthritis explored using network pharmacology and animal experimentation.
TSA can potentially ameliorate inflammation, safeguard knee cartilage tissue, and alleviate symptoms of KOA by inhibiting the MAPK/Akt/NF-κB signaling pathway.
Authors
- Wenhai Zhao (ORCID: https://orcid.org/0000-0002-9675-4477)
- Xiao Guo (ORCID: https://orcid.org/0000-0003-2268-5090)
- Qiang Chen (ORCID: https://orcid.org/0000-0003-2624-8904)
- Shiwei Zhuang (ORCID: https://orcid.org/0000-0001-8376-269X)
- Ye Qiu (ORCID: https://orcid.org/0000-0001-8451-8138)
Institutions
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.83153.17974
- Citations
- 2
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.61