EGCG attenuated spinal cord injury by inhibiting ferroptosis via activation of HMOX1 expression and suppression of HIF-1 signaling pathway.
Our findings reveal a significant new mechanism by which EGCG can reduce SCI through the inhibition of ferroptosis, facilitated by the activation of HMOX1 expression and the down-regulation of the HIF-1 signaling pathway. This suggests its potential as a therapeutic option for this condition.
Authors
- Jianping Kang (ORCID: https://orcid.org/0000-0001-6209-0695)
- Liuxu Chen
- Fei Ye (ORCID: https://orcid.org/0000-0002-2359-1486)
- Han Yang (ORCID: https://orcid.org/0000-0001-8994-7804)
- Linyu Yang
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.82651.17864
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Southwest Medical University