Rare case of non-Hodgkin lymphoma of the appendix and ileocecal valve presenting as acute perforated appendicitis

Non-Hodgkin lymphoma of the gastrointestinal tract is one of the least common primary malignancies, with diffuse large B-cell lymphoma being the most common histological subtype. Primary appendiceal lymphoma is extremely rare, with symptoms usually mimicking those of acute appendicitis. Here, we present a rare case of primary appendiceal non-Hodgkin lymphoma with ileocecal valve involvement and coexistence of <i>Schistosoma</i> eggs. The patient was initially diagnosed with acute perforation appendicitis. Following laparoscopic appendectomy, the patient developed an enterocutaneous fistula, which was addressed surgically after the failure of conservative management. Adjuvant chemotherapy with R-CHOP regimen was further planned for the patient.