Differences in baseline and dynamic plasma/saliva endocrine and linear/non-linear heart measures between patients with major depression and closely-matched healthy subjects: A 3-day combined overnight dexamethasone/metyrapone challenge study
Our detailed baseline and dynamic neuroendocrine comparison using closely matched HC indicates fewer neuroendocrine alterations in MDD than expected. These results challenge prior findings and support the importance of exact matching when investigating neuroendocrine biomarkers, as previously reported findings may rely on unaccounted individual but not group differences.
Authors
- Oliver Stiedl (ORCID: https://orcid.org/0000-0002-4427-9221)
- Alexandra Heinig
- Agorastos Agorastos (ORCID: https://orcid.org/0000-0003-4801-4957)
- Torben Hager
- Klaus Wiedemann (ORCID: https://orcid.org/0000-0003-3630-4201)
- Anne Sommer
- Cüneyt Demiralay (ORCID: https://orcid.org/0000-0002-8204-5477)
Institutions
- Universität Hamburg (DE)
- Aristotle University of Thessaloniki (GR)
- University Medical Center Hamburg-Eppendorf (DE)
- Cognitive Research (United States) (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.jpsychires.2025.05.020
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00