Polyneuropathy due to n-Hexane Intoxication – A Case Series

n -Hexane, a volatile organic chemical, is notorious for its neurotoxicity in occupational settings. We present four patients working in a needle manufacturing factory who presented with polyneuropathy after exposure to n -hexane by inhalation. Cerebrospinal fluid showed albuminocytological dissociation. Nerve conduction study (NCV) showed primary demyelination with secondary axonal polyneuropathy. Excluding the other possible causes, the diagnosis of n -hexane neuropathy was kept. Patients were managed with symptomatic treatment and showed marked improvement in 6-month follow-up.

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Publication Details

Journal
Annals of Indian Academy of Neurology
Published
2025-05-09
DOI
https://doi.org/10.4103/aian.aian_39_25
Citations
1
Primary Topic
Carcinogens and Genotoxicity Assessment
Type
article
Field-Weighted Citation Impact
0.94
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article

Polyneuropathy due to n-Hexane Intoxication – A Case Series

Khichar Shubhakaran, Pradeep Lalwani, Nidhi Yadav
1 citations
Annals of Indian Academy of Neurology
Carcinogens and Genotoxicity Assessment
0.94
article

Polyneuropathy due to n-Hexane Intoxication – A Case Series

Khichar Shubhakaran, Pradeep Lalwani, Nidhi Yadav
article en
1 citations

Abstract

n -Hexane, a volatile organic chemical, is notorious for its neurotoxicity in occupational settings. We present four patients working in a needle manufacturing factory who presented with polyneuropathy after exposure to n -hexane by inhalation. Cerebrospinal fluid showed albuminocytological dissociation. Nerve conduction study (NCV) showed primary demyelination with secondary axonal polyneuropathy. Excluding the other possible causes, the diagnosis of n -hexane neuropathy was kept. Patients were managed with symptomatic treatment and showed marked improvement in 6-month follow-up.

Annals of Indian Academy of NeurologyVol. 28(4)
Good health and well-being
Openalex Percentile: Top 25%
Carcinogens and Genotoxicity Assessment
0.94
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