Increased locomotor activity does not mitigate the effects of advanced maternal age in a mouse model
Our model reproduced previously-reported effects of age on fetal development and placental transcriptomics, but these were not mitigated by increased voluntary locomotor activity, despite a reduction in adiposity. Remarkably, increased voluntary locomotor activity had almost no effects on placental gene expression in aged mice.
Authors
- Katrina Williams
- Julian K. Christians (ORCID: https://orcid.org/0000-0003-1797-0591)
- Jess C. Hercus (ORCID: https://orcid.org/0000-0002-2703-1806)
- Daniel Alejandro Salcedo Rubio
- Cheayeong Keum
- Maria Elisa Osorio Nieto
- Caitlin D M Spreeuw
Institutions
- Simon Fraser University (CA)
Publication Details
- Journal
- Placenta
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.placenta.2025.05.007
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00