Lactate Facilitates Pancreatic Repair Following Acute Pancreatitis by Promoting Reparative Macrophage Polarization
Lactate facilitates pancreatic repair by promoting reparative macrophage polarization, achieved through promoting lactylation and inhibiting JAK2-STAT1 signaling. This phenotypic shift alleviates inflammation and facilitates tissue recovery, highlighting a potential therapeutic approach for AP.
Authors
- Jianbo Ni (ORCID: https://orcid.org/0000-0002-1219-9083)
- Zengkai Wu (ORCID: https://orcid.org/0000-0001-5352-7373)
- Jie Shen (ORCID: https://orcid.org/0000-0002-5988-8652)
- Xuerui Jin
- Guoyong Hu
- Ruiyan Wang (ORCID: https://orcid.org/0000-0001-5560-6841)
- Xiaolu Ge (ORCID: https://orcid.org/0000-0002-5533-7749)
- Jingpiao Bao (ORCID: https://orcid.org/0000-0003-1285-142X)
- Xingpeng Wang (ORCID: https://orcid.org/0000-0001-5167-8725)
- Pengli Song
- Jing Jiang (ORCID: https://orcid.org/0000-0001-9714-9255)
- Bin Li (ORCID: https://orcid.org/0000-0002-8607-8874)
- Peng Qi (ORCID: https://orcid.org/0000-0002-5048-9604)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101535
- Citations
- 7
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 14.04