PNPLA3 I148M variant links to adverse metabolic traits in MASLD during fasting and feeding
The <i>PNPLA3</i> rs738409 (p.I148M) polymorphism is the most prevalent genetic risk factor for metabolic dysfunction-associated steatotic liver disease progression and is influenced by fasting and feeding cycles. However, the pathophysiological consequences of this regulation remain poorly understood. Nuclear magnetic resonance-proteometabolomics reveals a distinct signature in homozygous <i>PNPLA3</i> GG carriers that changes significantly with fasting status, providing important implications for diagnosis and preventive strategies.
Authors
- Bandik Föh (ORCID: https://orcid.org/0000-0001-8793-7418)
- Monika Rau (ORCID: https://orcid.org/0000-0003-1219-4044)
- Friedhelm Sayk (ORCID: https://orcid.org/0000-0002-3437-3265)
- Marcin Krawczyk (ORCID: https://orcid.org/0000-0002-0113-0777)
- Andrea Schenk
- Sebastian M. Meyhöfer (ORCID: https://orcid.org/0000-0003-2034-5922)
- Andreas Geier
- Darko Castven (ORCID: https://orcid.org/0000-0002-2038-1408)
- Ulrich L. Günther (ORCID: https://orcid.org/0000-0001-9840-5943)
- Álvaro Mallagaray (ORCID: https://orcid.org/0000-0001-5825-4407)
- Susanne N. Weber (ORCID: https://orcid.org/0000-0002-5531-175X)
- Lorena Rudolph (ORCID: https://orcid.org/0000-0002-0218-2747)
- Lina Jegodzinski
- Ashok K. Rout (ORCID: https://orcid.org/0000-0003-1448-300X)
- Jörn M. Schattenberg (ORCID: https://orcid.org/0000-0002-4224-4703)
- Laura Hölzen
- Jens U. Marquardt (ORCID: https://orcid.org/0000-0002-8314-2682)
- Svenja Meyhöfer (ORCID: https://orcid.org/0000-0003-2425-7022)
Institutions
- Carl von Ossietzky Universität Oldenburg (DE)
- University Hospital Schleswig-Holstein (DE)
- Universitätsklinikum Würzburg (DE)
- Novo Nordisk (Germany) (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Duisburg-Essen (DE)
- Saarland University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101450
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Bundesministerium für Bildung und Forschung
- Else Kröner-Fresenius-Stiftung
- Universität zu Lübeck