Shifting Trends in the Causative Mycobacterial Agents of Urinary Tract Infection and their Sensitivity Pattern on Antibiograms in Female Diabetic Patients

Background: It is important to avoid using broad spectrum therapy for Urinary Tract Infections as it can contribute to drug resistance. A quick analysis of causative agent and their antibiograms is necessary for cost effective empirical therapy.Objectives: To determine the bacteria profile in urine sample of Urinary Tract Infections in diabetics and to determine the antibiotic susceptibility and sensitivity patterns of those bacteria.Materials and Methods: It was a descriptive type of cross sectional study conducted in of Bacha Khan Medical Complex Swabi for 3 months.Results: A total of 280 samples were collected from the microbiology lab. Out of which 234 were E. coli (83.6%), 16 were Klebsiella Pneumonia (5.7%), 13 were Proteus Mirabilis (4.6%), 10 were Pseudomonas (3.6%), 7 were Enterococcus faecalis (2.5%). Resistance was found for Amoxicillin+clauvulanic acid and Ciprofloxacin, while the organisms were found to be highly sensitive to Ertapenem, Meropenem, Imipenem and 100% sensitive to vancomycin.Conclusion: The most dominant organism was E.coli in culture and sensitivity reports followed by Klebsiella pneumonia then Proteus mirabilis, Pseudomonas and Enterococcus faecalis. Among antibiotics ciprofloxacin and amoxicillin showed least sensitivity in Urinary Tract Infections patients with diabetes and most effective antibiotics in the previous researches (doxycycline and cefepime) also showed alarmingly less sensitivity to uropathogens found in diabetics. The thing that stood out was that all these pathogens were highly sensitive to Imipenem, Meropenem, Ertapenem and Vancomycin. Keywords: Diabetes Mellitus, Resistance, Sensitivity, Urinary Tract Infections (UTI), Uropathogen.