Metachronous Periampullary Metastasis from Carcinoma Breast: An Unusual Clinical Presentation

Abstract Breast cancer is the most common malignancy in females and the leading cause of mortality in females among all malignancies. Distant metastasis to the bone, lungs, liver, and brain are commonly found in them, but gastrointestinal involvement is rare. Direct extrahepatic involvement without the liver is exceptional, and we report one of these rare cases that presented with obstructive jaundice due to metastasis from breast cancer to the periampullary region. This case emphasizes the role of tissue histopathology and immunochemistry profile to include the possibility of biliary localization of metastasis from primary breast cancer as a differential diagnosis of obstructive jaundice.