Effect of the Polymorphic Variant p.D1472H on the Platelet‐Dependent VWF Activity Assays
Our results for the first time show that VWF:GPIbR LIA, despite using ristocetin, is not affected by p.D1472H; hence, it offers reliable results to differentiate VWF quantitative from qualitative deficiencies. We further confirmed that VWF:RCo is highly compromised by p.D1472H, while VWF:GPIbR CLIA is unaffected. VWF:GPIbM LIA results were significantly lower in the p.D1472H (+) subjects than those in p.D1472H (-).
Authors
- Paola Colpani (ORCID: https://orcid.org/0000-0003-4180-6011)
- Omid Seidizadeh (ORCID: https://orcid.org/0000-0002-6630-7879)
- Emanuela Pappalardo (ORCID: https://orcid.org/0000-0002-4808-0498)
- Giovanna Cozzi (ORCID: https://orcid.org/0000-0002-0267-3773)
- Cristina Novembrino (ORCID: https://orcid.org/0000-0003-1450-9935)
- Flora Peyvandi (ORCID: https://orcid.org/0000-0001-7423-9864)
- M Pagliari (ORCID: https://orcid.org/0000-0003-0778-2271)
- Luciano Baronciani (ORCID: https://orcid.org/0000-0003-1186-6005)
- Andrea Cairo
- Lismaira Pati
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Haemophilia
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1111/hae.70060
- Citations
- 5
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.85