Biomarker profiling for infection diagnosis in emergency departments: A diagnostic study evaluating C-reactive protein, procalcitonin, Club Cell Protein 16, interleukin-6, chitinase-like protein, and soluble urokinase-type plasminogen activator recep
CRP, IL-6, and PCT showed the best diagnostic accuracy among the biomarkers tested but are influenced by the timing of symptom onset and fever presence. CC16, suPAR, and YKL-40 had poor diagnostic accuracy and were considered poor discriminators. Overall, no single biomarker was sufficient to conclusively rule in or rule out infection. These findings support the need for nuanced interpretation when using biomarkers to diagnose infections in ED settings.
Authors
- Anne Heltborg (ORCID: https://orcid.org/0000-0001-6451-2978)
- Christian Backer Mogensen (ORCID: https://orcid.org/0000-0002-8254-089X)
- Helene Skjøt‐Arkil (ORCID: https://orcid.org/0000-0002-2236-6375)
- Thor Aage Skovsted (ORCID: https://orcid.org/0000-0003-3147-3030)
- Claus Lohman Brasen (ORCID: https://orcid.org/0000-0001-8654-2449)
- Mariana Bichuette Cartuliares (ORCID: https://orcid.org/0000-0003-0923-6960)
- Roberta Bruhn (ORCID: https://orcid.org/0000-0002-5898-8168)
- Eva Rabing Brix Petersen
- Eline Sandvig Andersen (ORCID: https://orcid.org/0000-0001-5461-6976)
- Antoní Torres (ORCID: https://orcid.org/0000-0002-8643-2167)
- Marshall I. Hertz (ORCID: https://orcid.org/0000-0002-8064-7642)
Institutions
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Region of Southern Denmark (DK)
Publication Details
- Journal
- Clinical Biochemistry
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.clinbiochem.2025.110943
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Syddansk Universitet