IN VITRO BLOOD FLOW MODELING: ROLE IN PHARMACEUTICAL DEVELOPMENT, PROCESS METHODOLOGY AND FUTURE PROSPECTS

Abstract. Modern pharmaceutical development requires the creation of robust models that achieve the closest possible conditions to human physiology. The strategy for selecting the optimal modeling approach is based on the established goals of the experiment, the material and technical equipment of a particular laboratory, and the staffing of the research team. At the same time, there is now a clear need in the scientific and medical community to develop the most effective experimental models possible to simplify and accelerate the process of introducing new drugs. This is most important for nosologies critical for modern healthcare, an example of which are cardiovascular diseases, malignant neoplasms of various localizations and many others. For these pathological processes it is reasonable to use in vitro models of vascular blood flow. As a rule, the existing models described in international scientific databases are represented by complex modular designs consisting of one or several pumps, a reservoir with working fluid and a system of tubes. At the same time, each of the models we reviewed, despite their many merits, has several significant limitations potentially critical to further research. Based on the totality of all of the above nuances, we have critically evaluated the current trends and proposed methods to improve them, which we intend to implement in future research projects. Thus, in the present research work we have characterized the existing need for in vitro models, described the main parameters of the developed systems and outlined possible directions for their modification.