Predictive factors for pCR and relapse following neoadjuvant dual HER2-blockade in HER2+ breast cancer: an international cohort study
Our real-world data demonstrates that a comprehensive approach considering pCR, age, HR status, and nodal involvement is essential for personalized treatment strategies. These factors should be taken into account when deciding whether to escalate or de-escalate treatment, contributing to improved HER2+ BC patient outcomes.
Authors
- Silvia Artacho Criado
- Paulo Luz (ORCID: https://orcid.org/0000-0002-3905-0238)
- João Guilherme Costa (ORCID: https://orcid.org/0000-0002-5604-6142)
- Miguel Esperança‐Martins (ORCID: https://orcid.org/0000-0002-6858-7341)
- Ana S. Fernandes (ORCID: https://orcid.org/0000-0001-6350-0641)
- Inês Soares de Pinho (ORCID: https://orcid.org/0000-0002-8377-0179)
- Vanessa Pérez (ORCID: https://orcid.org/0000-0003-0586-3019)
- Diana Simão (ORCID: https://orcid.org/0000-0001-7638-9129)
- Elias A. Gracia Medina
- Luís Costa (ORCID: https://orcid.org/0000-0002-4782-7318)
- Amanda Manuella Dantas Nobre
- João Gregório
- Rita Freitas (ORCID: https://orcid.org/0009-0002-7059-1312)
- Lisa Gonçalves (ORCID: https://orcid.org/0000-0002-3431-5217)
- Raquel Lopes-Brás
- Maria Roldán Galnares
- Rita Sousa (ORCID: https://orcid.org/0000-0002-9147-7896)
- Joana Gonçalves
- Isabel M. Saffie Vega
Institutions
- Universidad de Alcalá (ES)
- Instituto de Oncología y Radiobiología (CU)
- Unidade Local de Saúde de Entre Douro e Vouga (PT)
- Hospital Virgen del Valle (ES)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Fundación Arturo López Pérez (CL)
- Hospital Universitario de Valme (ES)
- Universidade Lusófona (PT)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1007/s12094-025-03937-7
- Citations
- 5
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Universidade Lusófona de Humanidades e Tecnologias
- Fundação para a Ciência e a Tecnologia