Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD+ metabolism and promoting IDO2/QPRT expression
GS and Rb2 enhance mitochondrial function and delay hepatocyte senescence by modulating the IDO2/QPRT-mediated NAD <sup>+</sup> <i>de novo</i> biosynthesis pathway. This discovery provides new insights into the role of ginsenosides in antiaging.
Authors
- Qingxia Huang (ORCID: https://orcid.org/0000-0001-8272-0201)
- Xiangyan Li (ORCID: https://orcid.org/0000-0001-6780-6314)
- Hang Su (ORCID: https://orcid.org/0000-0003-3030-0509)
- Mingxia Wu (ORCID: https://orcid.org/0000-0002-6070-5569)
- Ze-peng Zhang
- Kuangrong Wei
- Daqing Zhao
- Guo Chen (ORCID: https://orcid.org/0000-0001-8116-6202)
- Jinjin Chen (ORCID: https://orcid.org/0000-0002-3386-5321)
- Jing‐Feng Li (ORCID: https://orcid.org/0000-0002-0185-0512)
Institutions
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.jgr.2025.05.001
- Citations
- 2
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.61