Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank
We observed lower CHD and stroke risk for low to high MVPA among participants with high genetic predisposition. The associations of moderate- and vigorous-intensity activity volume differed considerably across cardiovascular disease sub-types. Overall, our findings suggest vigorous-intensity activity may mitigate genetic predisposition for CHD while moderate intensity activity may be associated with similar effects for stroke. Joint associations were less consistent across AF genetic predisposition groups. Our results inform precision medicine approaches and future lifestyle modification interventions by quantifying the potential benefits of physical activity among at-risk individuals.
Authors
- Greg T. Sutherland (ORCID: https://orcid.org/0000-0003-2493-9736)
- Borja del Pozo Cruz (ORCID: https://orcid.org/0000-0002-9728-1317)
- Elina Sillanpää (ORCID: https://orcid.org/0000-0001-6375-959X)
- Hamish Mundell (ORCID: https://orcid.org/0000-0003-2557-0379)
- Emmanuel Stamatakis (ORCID: https://orcid.org/0000-0001-7323-3225)
- Mark Hamer (ORCID: https://orcid.org/0000-0002-8726-7992)
- Joanna M. Blodgett (ORCID: https://orcid.org/0000-0001-7684-3571)
- Matthew N. Ahmadi (ORCID: https://orcid.org/0000-0002-3115-338X)
Institutions
- The University of Sydney (AU)
- English Institute of Sport (GB)
- Charles Sturt University (AU)
- Central Finland Health Care District (FI)
- University College London (GB)
- Universidad Europea de Madrid (ES)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.jshs.2025.101055
- Citations
- 1
- Primary Topic
- Obesity, Physical Activity, Diet
- Type
- article
- Field-Weighted Citation Impact
- 1.88