The synergistic effect of imipenem combined with ceftazidime-avibactam against Klebsiella pneumoniae with alternating resistance to CZA and carbapenem
This study revealed that CRKP developed CZA resistance due to bla<sub>KPC</sub> mutation, and carbapenem susceptibility was restored. After retreatment with carbapenem, the strains showed carbapenem resistance, and they regained susceptibility to CZA. For the first time, we showed that the bla<sub>KPC</sub> mutation was reversible. For such clinical isolates, the combination of IMP and CZA could delay or prevent mutations in bla<sub>KPC</sub> and have a synergistic effect.
Authors
- Min Jiang (ORCID: https://orcid.org/0000-0003-2946-6974)
- Yunying Wang (ORCID: https://orcid.org/0009-0003-1843-6566)
- 迪子 鈴木
- Xiaowei Zhan
- Wei Wei (ORCID: https://orcid.org/0000-0003-3869-2631)
- Simin Liu (ORCID: https://orcid.org/0000-0003-2098-3844)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- People's Hospital of Kaizhou District (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.jmii.2025.04.005
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00