Utility of Discrepancies Between Friedewald and Martin Equations in Predicting Pathogenic Variants of Familial Hypercholesterolemia in Children
Discrepancies in LDL-C levels measured by the Friedewald and Martin equations might serve as a useful predictive marker for identifying pathogenic variants of FH, especially in cases of LDL-C <180 mg/dL, which are often challenging to diagnose.
Authors
- Kanako Irie
- Ichiro Yokota
- Keiji Matsunaga (ORCID: https://orcid.org/0000-0003-3611-1143)
- Masayuki Takamura (ORCID: https://orcid.org/0000-0002-1540-4417)
- Sumiko Yoshida (ORCID: https://orcid.org/0000-0002-1751-3641)
- Takashi Kusaka (ORCID: https://orcid.org/0000-0003-0790-737X)
- Tsuyoshi Sasaki (ORCID: https://orcid.org/0000-0002-1210-1699)
- Tomoko Inoue (ORCID: https://orcid.org/0000-0001-5504-9352)
- Yoichi Hoshikawa
- Katsufumi Nishioka
- Sonoko Kondo (ORCID: https://orcid.org/0009-0005-9671-4300)
- Katsunori Yokoyama
- Ryosuke Tani (ORCID: https://orcid.org/0000-0003-4831-567X)
- Takashi Iwase
- Hayato Tada (ORCID: https://orcid.org/0000-0002-3357-1809)
- Shigeru Ito
- Hai Ying Fu
- Takuji Fujisawa
- Tetsuo Minamino (ORCID: https://orcid.org/0000-0002-5424-4081)
Institutions
- Kanazawa University (JP)
- Kagawa University (JP)
- Fujisawa City Hospital (JP)
- Mito Saiseikai General Hospital (JP)
- National Hospital Organization (JP)
- Kagawa Prefectural Central Hospital (JP)
- Shikoku Medical Center for Children and Adults (JP)
- Chiba Prefectural Government (JP)
- Hyogo University (JP)
Publication Details
- Journal
- Circulation Journal
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1253/circj.cj-24-0928
- Citations
- 3
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science