Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis
Ovariectomy for six months independently induced an aberrant cholesterol phenotype in mice. Downregulation of PRKRA was implicated in cholesterol metabolism disturbances related to menopause, potentially through the regulation of cholesterol synthesis and LDL uptake.
Authors
- Le Xu (ORCID: https://orcid.org/0000-0003-0931-5482)
- Zou Shi-en
- Sa Zhang
- Ting Guo (ORCID: https://orcid.org/0000-0002-4092-3198)
- Jian Xu (ORCID: https://orcid.org/0000-0001-7802-0413)
- Wanting Shi (ORCID: https://orcid.org/0000-0002-0209-0930)
Institutions
- Taiyuan Maternity and Child Care Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1186/s12944-025-02575-w
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China