RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study
For a given reduction in apoB levels, genetically predicted reductions in PCSK9 function (mimicking PCSK9 neutralizing antibodies) and liver PCSK9 gene expression levels (mimicking PCSK9 RNA interference) were comparably associated with a lower risk of coronary artery disease. These genetic data suggest that LDL-C/apoB reductions may provide cardiovascular benefits, regardless of how PCSK9 function is inhibited.
Authors
- Audrey Paulin (ORCID: https://orcid.org/0000-0002-1224-9538)
- Kausik Kumar Ray (ORCID: https://orcid.org/0000-0003-0508-0954)
- Éloi Gagnon (ORCID: https://orcid.org/0000-0002-7483-1371)
- Jérôme Bourgault (ORCID: https://orcid.org/0000-0002-5803-353X)
- Christian Couture (ORCID: https://orcid.org/0000-0003-1063-8780)
- Émilie Gobeil (ORCID: https://orcid.org/0000-0002-5365-0731)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Patricia L. Mitchell (ORCID: https://orcid.org/0000-0002-0773-1047)
- Sébastien Thériault (ORCID: https://orcid.org/0000-0003-1893-8307)
- Benoît J. Arsenault (ORCID: https://orcid.org/0000-0003-2240-8456)
- Patrick Mathieu (ORCID: https://orcid.org/0000-0002-3805-2004)
- Arnaud Girard (ORCID: https://orcid.org/0000-0002-8219-9118)
- Yohan Bossé (ORCID: https://orcid.org/0000-0002-3067-3711)
- John J.P. Kastelein (ORCID: https://orcid.org/0000-0003-2018-4532)
- André Tchernof (ORCID: https://orcid.org/0000-0002-2587-1000)
- Marie‐Claude Vohl
Institutions
- Amsterdam UMC Location University of Amsterdam (NL)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
- Imperial College London (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1093/cvr/cvaf078
- Citations
- 3
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Université Laval
- Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé