The incidence of anti-HMGCR immune-mediated necrotizing myopathy: an Australian and UK retrospective multi-site cohort study
For the first time, we have calculated an incidence of anti-HMGCR IMNM using a large, multinational cohort. We highlight the refractory nature of anti-HMGCR IMNM. We also describe the unique phenotype of statin-naïve anti-HMGCR IMNM, and the rare occurrence of self-limiting myopathy.
Authors
- Amir Reza Bahadori (ORCID: https://orcid.org/0000-0003-1275-1138)
- Thomas Khoo (ORCID: https://orcid.org/0000-0003-1122-3384)
- James B Lilleker (ORCID: https://orcid.org/0000-0002-9230-4137)
- Xia Lyu (ORCID: https://orcid.org/0000-0001-5722-306X)
- Vidya Limaye (ORCID: https://orcid.org/0000-0002-8142-9532)
- Anna Brusch
- Ross Sadler (ORCID: https://orcid.org/0000-0003-2250-670X)
- Maya H Buch (ORCID: https://orcid.org/0000-0002-8962-5642)
- Maciej Tomaszewski (ORCID: https://orcid.org/0000-0001-8215-6567)
- Merrilee Needham (ORCID: https://orcid.org/0000-0001-6591-1444)
- Hector Chinoy (ORCID: https://orcid.org/0000-0001-6492-1288)
- Janine A. Lamb (ORCID: https://orcid.org/0000-0002-7248-0539)
- Keziah Austin (ORCID: https://orcid.org/0000-0002-8827-3198)
- Elina Tan
- Harsha Gunawardena (ORCID: https://orcid.org/0009-0001-2197-5582)
Institutions
- North Bristol NHS Trust (GB)
- Royal Adelaide Hospital (AU)
- Murdoch University (AU)
- Manchester Academic Health Science Centre (GB)
- Royal Perth Hospital (AU)
- Renji Hospital (CN)
- Fiona Stanley Hospital (AU)
- Salford Royal NHS Foundation Trust (GB)
- Churchill Hospital (GB)
- Manchester Royal Infirmary (GB)
- Sir Charles Gairdner Hospital (AU)
- University of Manchester (GB)
- Queen Elizabeth II Medical Centre (AU)
- Manchester University NHS Foundation Trust (GB)
- Women's and Children's Health Network (AU)
- Salford Royal Hospital (GB)
- Perron Institute for Neurological and Translational Science (AU)
- Oxford University Hospitals NHS Trust (GB)
- NIHR Manchester Biomedical Research Centre (GB)
- Pathwest Laboratory Medicine (AU)
- The University of Adelaide (AU)
- Manchester University (US)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1093/rheumatology/keaf238
- Citations
- 5
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Australian Government
- National Institute for Health and Care Research
- Department of Health and Social Care
- Arthritis Australia
- Manchester Biomedical Research Centre