Molecular characterisation of the residual disease after neoadjuvant endocrine therapy in ER+/HER2- breast cancer uncovers biomarkers of tumour response
Our findings highlight the change of intrinsic subtype from luminal A to normal-like after NET as a putative biomarker characterising the patient population that obtains the highest benefit from NET. Our study also suggests that changes in PAM50-derived ROR score and p53 evaluation could also help to identify those patients. Thus, this study uncovers potential biomarkers of response to NET and prognosis, which should be validated in independent cohorts, helping to the implementation of NET in the clinical practice.
Authors
- Sara Manzano (ORCID: https://orcid.org/0000-0002-0052-511X)
- Marta Férnandez (ORCID: https://orcid.org/0000-0001-9271-1632)
- Isabel Álvarez (ORCID: https://orcid.org/0000-0001-8958-0694)
- Elvira Buch (ORCID: https://orcid.org/0000-0001-7800-9935)
- Luis Álvarez (ORCID: https://orcid.org/0000-0002-0673-7439)
- María M. Caffarel (ORCID: https://orcid.org/0000-0002-7442-6827)
- María Otaño (ORCID: https://orcid.org/0000-0001-7053-1817)
- Inge Etxabe
- Sofía Aragón-Sánchez (ORCID: https://orcid.org/0000-0002-7438-3812)
- Kepa Elorriaga
- Joanna I. López-Velazco (ORCID: https://orcid.org/0000-0001-5620-6495)
- Laia Paré (ORCID: https://orcid.org/0000-0002-4904-558X)
- Ainhara Lahuerta
- Ander Urruticoechea (ORCID: https://orcid.org/0000-0003-0359-3641)
- Vanesa Quiroga (ORCID: https://orcid.org/0000-0002-7852-474X)
- Aleix Prat (ORCID: https://orcid.org/0000-0003-2377-540X)
- Julia Giménez
- Miren Huarte
Institutions
- Ikerbasque (ES)
- Institut Català d'Ornitologia (ES)
- Basque Government (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Biogipuzkoa Health Research Institute (ES)
- Fundación Instituto Valenciano de Oncología (ES)
- Institut Català d'Oncologia (ES)
- Hospital Clínic de Barcelona (ES)
- Onkologikoa (ES)
- Bioef - Fundación Vasca de Innovación e Investigación Sanitarias (ES)
- INCLIVA Health Research Institute (ES)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.tranon.2025.102407
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94