Comparative Evaluation of Deep Learning Models in Alzheimer’s Disease Diagnosis

Alzheimer’s Disease (AD) is an ever-evolving neurodegenerative confusion that influences the neurons of the mind in a manner that hinders the patients’ ability to solve problems and remember issues and that requires timely and proper identification to enable appropriate management and treatment. Based on MRI medical images, deep learning models have become one of the most effective approaches for analyzing the signs of the early stages of AD. This research, therefore, carries out a comparative analysis of five deep learning models such as Convolutional Neural Networks (CNNs) like AlexNet, VGGNet, and ResNet, as well as Long Short-Term Memory (LSTM) networks and 3D Convolutional Neural Networks (3D-CNNs) in the finding of Alzheimer’s Sickness from medical imaging data. Each model’s arrangement parameters, for example, layer configurations, learning rate, batch size, optimizer, number of epochs, loss function, applying techniques for regularization, activation functions, and the input dimensions, using pre-trained weights, were carefully initialized to yield a proper comparison between the models. Diagnostic performances were evaluated utilizing precision, responsiveness(recall), specificity, and region under the receiver operating characteristic curve (AUC-ROC). ResNet outperformed other profound learning models in diagnosing Alzheimer’s Disease from MRI scans with a precision of 0.91 and AUC-ROC of 0.95. At the same time, VGGNet, AlexNet, LSTM, and 3D-CNNs demonstrated varying strengths and limitations in balancing accuracy, computational efficiency, and feature extraction.