High human papillomavirus viral load and local immune dysregulation are associated with poor clinical outcomes in patients with cervical cancer
The viral load of HPV in cervical cancer correlates positively to metastasis and recurrence and negatively to survival rates, potentially because of local immune suppression. These results might indicate a lower response to immune checkpoint inhibition in the high viral load group and that other treatment options should still be explored.
Authors
- Gregor G. W. van Bochove (ORCID: https://orcid.org/0000-0001-8564-5956)
- Luc R.C.W. van Lonkhuijzen (ORCID: https://orcid.org/0000-0001-6905-2704)
- Lukas J.A. Stalpers (ORCID: https://orcid.org/0000-0001-9574-0295)
- Xionge Mei (ORCID: https://orcid.org/0000-0001-8697-2721)
- Louis Vermeulen (ORCID: https://orcid.org/0000-0002-6066-789X)
- C.B.M. van den Broek
- Marloes IJff (ORCID: https://orcid.org/0000-0002-0921-2398)
- Constantijne H. Mom (ORCID: https://orcid.org/0000-0003-2838-2031)
- Willem de Koning (ORCID: https://orcid.org/0000-0002-4594-8423)
- Johannes Crezee (ORCID: https://orcid.org/0000-0002-7474-0533)
- Arlene L. Oei (ORCID: https://orcid.org/0000-0002-6936-1934)
- Renske D.M. Steenbergen (ORCID: https://orcid.org/0000-0002-2327-9839)
- Timo L.M. ten Hagen
- Jan Köster (ORCID: https://orcid.org/0000-0002-0890-7585)
- Seth‐Frerich Fobian
- Andrew Stubbs (ORCID: https://orcid.org/0000-0001-9817-9982)
Institutions
- Dutch Cancer Society (NL)
- Amsterdam Neuroscience (NL)
- Oncode Institute (NL)
- Centrum voor Gynaecologische Oncologie Amsterdam (NL)
- Erasmus MC Cancer Institute (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- International Journal of Gynecological Cancer
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.ijgc.2025.101924
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Amsterdam University Medical Centers
- National Research Foundation
- China Scholarship Council
- KWF Kankerbestrijding