Seizures influence sleep macrostructure and the sleep–wake circadian rhythm in Dravet syndrome
Our study shows a significant effect of epileptic phenomena on sleep macrostructure in DS. Motor seizures and IEDs influence slow wave sleep, which could be one of the mechanisms that sustain encephalopathy in DS. Interestingly, fenfluramine seems to have a protective effect on this mechanism, both by stabilizing sleep and as an ASM.
Authors
- Francesca Darra (ORCID: https://orcid.org/0000-0002-1062-8438)
- Leslie Rinaldi (ORCID: https://orcid.org/0000-0002-3897-2556)
- Jacopo Proietti (ORCID: https://orcid.org/0000-0002-5584-4724)
- Ludovica Ghobert (ORCID: https://orcid.org/0000-0001-9098-1575)
- Gaetano Cantalupo (ORCID: https://orcid.org/0000-0003-1343-8434)
- Alberto Cossu (ORCID: https://orcid.org/0000-0001-6945-6151)
- Bernardo Dalla Bernardina
Institutions
- University of Verona (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1111/epi.18451
- Citations
- 4
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.88