Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI
These results provided a novel understanding of detailed and unbiased cellular landscape of WAT in breast cancer with high BMI from single-cell atlas perspective, uncovering interplays between breast adipose-infiltrating immune cells and stromal cells that promote progression of BC under high BMI conditions.
Authors
- Fang Jia (ORCID: https://orcid.org/0000-0002-7738-8491)
- Wuzhen Chen (ORCID: https://orcid.org/0000-0003-0210-6645)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-9289-4889)
- Xia Li (ORCID: https://orcid.org/0000-0002-9794-2648)
- Xiaoxiao Hu (ORCID: https://orcid.org/0000-0003-4570-6464)
- Leyi Zhang (ORCID: https://orcid.org/0000-0002-0266-3663)
- Jun Pan (ORCID: https://orcid.org/0000-0002-4031-5766)
- Jian Huang (ORCID: https://orcid.org/0000-0003-3340-5007)
- Sangsang Zhu
Institutions
- Zhejiang Cancer Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1016/j.tranon.2025.102408
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China