Impact of PlGF immunoassay imprecision on preeclampsia risk assessment with the sFlt-1 to PlGF ratio
Despite the suboptimal precision observed at low QC levels and potential drifts in PlGF results, the sFlt-1 to PlGF ratio remains a reliable tool for preeclampsia risk assessment. This study highlights the need for critical evaluation of analytical performance beyond FDA approval and the importance of assessing the potential impact of assay imprecision on patient care for individual biomarkers.
Authors
- Guanmin Chen
- Kiang-Teck J Yeo (ORCID: https://orcid.org/0000-0002-4708-8420)
- Sarosh Rana (ORCID: https://orcid.org/0000-0002-5828-7433)
- Clarence W. Chan (ORCID: https://orcid.org/0000-0001-5472-4803)
- Richard F Schaefer
Institutions
- University of Chicago (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1093/ajcp/aqaf032
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00