SERPINB10 promotes macrophage M2 polarization and airway inflammation in asthma
SERPINB10 promotes macrophage M2 polarization by suppressing IL-4Rα degradation and upregulating IL-4R signaling. SERPINB10 is a potential therapeutic target for asthma.
Authors
- Lingling Yi
- Chunli Huang (ORCID: https://orcid.org/0000-0002-1676-7375)
- Guohua Zhen (ORCID: https://orcid.org/0000-0001-5582-7900)
- Gongqi Chen (ORCID: https://orcid.org/0009-0009-4860-1335)
- Weiqiang Kong (ORCID: https://orcid.org/0009-0003-6935-4982)
- Wei Gu (ORCID: https://orcid.org/0000-0002-2723-0872)
- Wenliang Wu (ORCID: https://orcid.org/0000-0003-1103-7629)
- Lu Zhao (ORCID: https://orcid.org/0009-0000-9454-9800)
- Huiru Jie
Institutions
- National Health and Family Planning Commission (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1186/s12931-025-03252-3
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Tongji University