New ecdysteroids with anticomplementary activity from roots of <i>Leuzea uniflora</i> (L.) holub
Phytochemical investigation on roots extract of <i>Leuzea uniflora</i> (L.) Holub led to the isolation of two novel ecdysteroids, 11<i>α</i>-hydroxy-25<i>R</i>-inokosterone (1) and 11<i>α</i>-hydroxy-24<i>R</i>, 25 <i>R</i>-amarasterone A (2), along with 20 known constituents. The structures of novel compounds were confirmed by NMR and ECD spectroscopy. Compounds <b>2</b> and <b>9</b> exhibited anticomplementary activity with classical pathway, their CH<sub>50</sub> values were 138.4 ± 0.07 µg·mL<sup>-1</sup> and 158.3 ± 0.09 µg·mL<sup>-1</sup>, respectively.
Authors
- Yu‐Cheng Gu (ORCID: https://orcid.org/0000-0002-6400-6167)
- Ruo-mei Li
- Chun-hui Liang
- Ning‐Ning Shi
- Yannan Ji (ORCID: https://orcid.org/0000-0003-1070-9884)
- Manli Zhang (ORCID: https://orcid.org/0000-0002-7704-4525)
- Wenchao Du (ORCID: https://orcid.org/0009-0000-1271-2695)
- Can Liu (ORCID: https://orcid.org/0009-0006-8694-9322)
- Jinlong Qi
Institutions
- Hebei Medical University (CN)
- Shijiazhuang University (CN)
- Third Hospital of Hebei Medical University (CN)
- Syngenta (Switzerland) (CH)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1080/14786419.2025.2502855
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province