Thrombospondin-1 induces CD8+ T cell exhaustion and immune suppression within the tumor microenvironment of ovarian cancer
This study positions THBS1 as a key regulator of the OC TME, linking TAM recruitment and polarization to CD8<sup>+</sup> T cell exhaustion via immune checkpoint modulation. By identifying SNF2H as a transcriptional regulator of THBS1, we offer new insights into its epigenetic dysregulation and suggest potential therapeutic strategies to reprogram the TME and improve the effectiveness of immunotherapy.
Authors
- Suwei Zhang
- Haiyan Liang (ORCID: https://orcid.org/0009-0004-9854-9663)
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou Central Hospital (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1186/s13048-025-01668-5
- Citations
- 4
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22