Long-chain fatty acyl CoA synthetase 4 expression in pancreatic cancer: a marker for malignant lesions and prognostic indicator for recurrence
ACSL4 expression helps differentiate cancerous from precancerous lesions in pancreatic cancer, but low expression is linked to a higher frequency of lymphovascular invasion and shorter disease-free survival in invasive cases. Due to the limited sample size and broad confidence intervals, the findings of this study should be interpreted with caution and require validation in larger, independent cohorts.
Authors
- Yuichi Honma (ORCID: https://orcid.org/0000-0001-7112-3479)
- Michihiko Shibata
- Toshiyuki Nakayama (ORCID: https://orcid.org/0000-0002-3865-7169)
- Shinji Oe (ORCID: https://orcid.org/0000-0002-9623-3663)
- Koichiro Miyagawa
- Keiichiro Kumamoto
- Eisuke Katafuchi (ORCID: https://orcid.org/0009-0008-7169-4536)
- Yoshikazu Harada (ORCID: https://orcid.org/0000-0002-8845-2743)
- Daiki Uchihara
- Shohei Shimajiri
- Kōichi Nakamura (ORCID: https://orcid.org/0000-0003-2330-7032)
- Masaru Harada
- Fariza Nuratdinova
Institutions
- University of Occupational and Environmental Health Japan (JP)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1186/s13000-025-01659-6
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.75