Time to administer polymyxin B hemoperfusion and hemodynamics in patients with septic shock requiring high-dose norepinephrine: a predetermined analysis of a prospective cohort study
In patients with septic shock, early administration of PMX-HP was associated with higher mean arterial pressure and lower VIS within 48 h after ICU admission. Additionally, it may be associated with an improved clinical course, represented by more ICU-free and vasopressor/inotrope-free days. Trial registration UMIN Clinical Trial Registry on 1 November 2019 (registration no. UMIN000038302).
Authors
- Tsuyoshi Suzuki (ORCID: https://orcid.org/0009-0009-8355-0756)
- Kazunori Fukushima (ORCID: https://orcid.org/0000-0003-2207-4011)
- Kyohei Miyamoto (ORCID: https://orcid.org/0000-0001-5473-2731)
- Minori Kinjo
- Yu Kawazoe (ORCID: https://orcid.org/0000-0003-4471-4788)
- Tasuku Hanajima (ORCID: https://orcid.org/0000-0003-1428-4043)
- Tetsuya Sato (ORCID: https://orcid.org/0000-0002-1373-5810)
- Jun‐ichi Maruyama (ORCID: https://orcid.org/0000-0002-5318-5366)
- Satoru Murata (ORCID: https://orcid.org/0000-0001-7772-0821)
- Michihito Kyo (ORCID: https://orcid.org/0000-0002-2559-6440)
- Yukitoshi Toyoda
- Takeshi Morimoto (ORCID: https://orcid.org/0000-0002-6844-739X)
- Noriko Miyagawa (ORCID: https://orcid.org/0000-0002-7206-5829)
- Tomoya Okazaki (ORCID: https://orcid.org/0000-0002-0540-8772)
- Takuya Kimura
- Hiroshi Matsuura (ORCID: https://orcid.org/0000-0002-8618-0385)
- Hitoshi Yamamura (ORCID: https://orcid.org/0000-0003-1903-4879)
- Toshihiro Sakurai (ORCID: https://orcid.org/0009-0001-4480-7258)
- Gaku Takahashi (ORCID: https://orcid.org/0000-0002-5947-6295)
- Masaki Takahashi (ORCID: https://orcid.org/0000-0002-3615-2132)
- Yoshinori Ohta
Institutions
- Hiroshima University (JP)
- Fukushima Medical University (JP)
- Gunma University (JP)
- Iwate Medical University (JP)
- Hokkaido University (JP)
- Kyoto Medical Center (JP)
- Fukuoka University Hospital (JP)
- Tohoku University Hospital (JP)
- Sendai Medical Center (JP)
- Saiseikai Utsunomiya hospital (JP)
- Osaka Hospital (JP)
- Shizuoka General Hospital (JP)
- Kagawa University Hospital (JP)
- National Hospital Organization (JP)
- Kumamoto Medical Center (JP)
- Ehime University (JP)
- Nara Prefecture General Medical Center (JP)
- Nara Medical University (JP)
- Hyogo University (JP)
Publication Details
- Journal
- Critical Care
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13054-025-05422-7
- Citations
- 4
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Wakayama Medical University
- Toray Industries