Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1
This study highlights the crucial role of the BIN1/G3BP1/STAT1/CD8<sup>+</sup> tumor-infiltrating lymphocyte signaling pathway in the progression of NSCLC and its mechanisms of immune evasion. This fundings lay a foundation for the development of BIN1-targeted therapies aimed at improving tumor immunogenicity and transforming immunologically "cold" NSCLC into a more responsive disease.
Authors
- Lihua Liu (ORCID: https://orcid.org/0000-0002-1201-4624)
- Tianxu Liu (ORCID: https://orcid.org/0009-0002-7973-4025)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-7321-1202)
- Jiali Wang (ORCID: https://orcid.org/0000-0002-2934-4582)
- Jiaqi Chen (ORCID: https://orcid.org/0000-0002-1582-3195)
- Xinyan Liu (ORCID: https://orcid.org/0000-0002-7897-1400)
- Xiaoqing Xu (ORCID: https://orcid.org/0000-0002-6959-8667)
- Shuxian Yin
- Yunlong Jia
Institutions
- Hebei Medical University (CN)
- Capital Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Henan Cancer Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s13046-025-03404-9
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59