Functional immune profiling of hyper- and hypo-inflammatory subphenotypes of critical illness: a secondary analysis
These data further validate the use of IL-6, TNFR1 and bicarbonate to discern inflammatory sub-groups of patients with critical illness. They also confirm the observation that the presence of the hyper-inflammatory subphenotype is often accompanied by a compensatory anti-inflammatory response syndrome. Future investigations should focus on prospective validation of this panel for prognostic enrichment of clinical research studies.
Authors
- Shouhao Zhou (ORCID: https://orcid.org/0000-0002-8124-5047)
- Anthony Bonavia (ORCID: https://orcid.org/0000-0001-9596-001X)
- Daniel McKeone (ORCID: https://orcid.org/0000-0002-2106-3559)
- E. Scott Halstead (ORCID: https://orcid.org/0000-0002-1167-0363)
- Abigail Samuelsen
Institutions
- Pennsylvania State University (US)
- Department of Public Health (MM)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1520848
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Institute of General Medical Sciences