Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma
Our study reveals that the RMRM risk model could effectively predict the prognosis of HCC, and SPP1<sup>+</sup> macrophages regulated by miR-4739-RNA methylation promote the proliferation and migration of HCC cells. These results highlight the potential of RMRMs in predicting the prognosis of HCC.
Authors
- Yongfeng Hui (ORCID: https://orcid.org/0009-0001-1309-7767)
- Shaoqi Yang (ORCID: https://orcid.org/0000-0002-4377-1978)
- Pan Tian (ORCID: https://orcid.org/0000-0002-0195-6122)
- Yong Du (ORCID: https://orcid.org/0000-0003-1687-9024)
- Rong Su (ORCID: https://orcid.org/0009-0003-4765-6859)
Institutions
- Ningxia Medical University (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fonc.2025.1553239
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Ningxia Medical University