Cervical EVT isolation for non-invasive fetal HLA typing in early pregnancy is limited by purity and maternal cell contamination; a methodological comparison
EVT counts and maternal cell contamination limit reliable fetal HLA typing from cervical samples. Refining non-invasive EVT isolation techniques may enable fetal HLA typing to be included in risk assessment of pregnancy complications.
Authors
- Dave L. Roelen (ORCID: https://orcid.org/0000-0002-1846-1193)
- J.J.M. Drabbels (ORCID: https://orcid.org/0000-0002-0118-5145)
- Marie‐Louise van der Hoorn (ORCID: https://orcid.org/0000-0002-7781-7815)
- Liseanne van 't Hof (ORCID: https://orcid.org/0000-0002-1756-3825)
- Johanna M. Kapsenberg
- Michael Eikmans (ORCID: https://orcid.org/0000-0002-9648-4227)
- Lotte E. van der Meeren (ORCID: https://orcid.org/0000-0002-4537-5645)
Institutions
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1575086
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Amsterdam University Medical Centers
- Universiteit Leiden
- Ministry of Earth Sciences
- Leids Universitair Medisch Centrum