Uncovering key regulatory pathways and prognostic biomarkers in the tumor microenvironment of high-grade serous ovarian cancer through single-cell RNA sequencing and experimental validation
This study highlights the PTN signaling pathway as a potential therapeutic target in HGSOC and identifies SDC4 as a prognostic biomarker for poor patient outcomes. Our findings offer new insights into the molecular mechanisms governing the TME of HGSOC, although further investigation is needed to fully elucidate the functional role of SDC4 in ovarian cancer progression.
Authors
- Long Zhao (ORCID: https://orcid.org/0000-0003-2691-7055)
- Hui Luo (ORCID: https://orcid.org/0000-0002-9928-9718)
- Shucai Yang (ORCID: https://orcid.org/0000-0002-9694-828X)
- Chang Zou (ORCID: https://orcid.org/0000-0002-2003-7834)
- Qianqian Zhou (ORCID: https://orcid.org/0009-0001-7478-2477)
- Xia Liu (ORCID: https://orcid.org/0000-0001-5473-5596)
- Yue Li (ORCID: https://orcid.org/0000-0002-7727-905X)
- Ying Tian (ORCID: https://orcid.org/0000-0002-6031-2335)
- Jinling Zhang (ORCID: https://orcid.org/0000-0002-6017-7751)
- Jinfeng Xu (ORCID: https://orcid.org/0000-0002-4557-3406)
Institutions
- Southern University of Science and Technology (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fonc.2025.1591430
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province