Association of plasma concentration of trace metals with frontotemporal degeneration
Significant associations between plasma concentration of several trace metals and FTD. The significantly elevated levels of Manganese and Chromium may suggest a role of environmental exposure in the pathogenesis of FTD. However, larger, well-designed prospective studies, along with complementary experimental work, are needed to better elucidate this relationship.
Authors
- Russell P. Sawyer (ORCID: https://orcid.org/0000-0003-2426-1929)
- Rhonna Shatz (ORCID: https://orcid.org/0000-0003-3954-8148)
- Scott M. Langevin (ORCID: https://orcid.org/0000-0001-7031-1216)
- Roman Jandarov (ORCID: https://orcid.org/0000-0003-2145-045X)
- Brian P. Jackson
- Kelly DeLano (ORCID: https://orcid.org/0000-0001-6025-0472)
- Alex C Sprague
Institutions
- Dartmouth College (US)
- University of Vermont (US)
- Cincinnati Health Department (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fneur.2025.1593821
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cincinnati
- National Institutes of Health
- National Institute of Environmental Health Sciences