Role of CDH1 gene variants and E-cadherin localization in gastric mucosal cancerization
The A allele of the CDH1 gene rs16260 locus show no effect in gastric mucosal pathological evolution, while the elevated mRNA transcription levels potentially increasing the risk of gastric cancer. The loss and ectopic expression of E-cadherin may be significant risk factors for malignant transformation in the gastric mucosa.
Authors
- Ru‐Liu Li (ORCID: https://orcid.org/0000-0002-1046-6395)
- Weijing Chen (ORCID: https://orcid.org/0000-0001-7245-6531)
- Qi Luo (ORCID: https://orcid.org/0000-0001-8163-8935)
- Ling Hu (ORCID: https://orcid.org/0000-0003-3104-8050)
- Yunzhan Zhang
- Yunbo Wu (ORCID: https://orcid.org/0000-0002-0044-3288)
- Yunkai Dai (ORCID: https://orcid.org/0000-0002-1667-4670)
- Shaoyang Lan
- Chen Xu (ORCID: https://orcid.org/0000-0001-8022-532X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fonc.2025.1590680
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01