Multi-omics technology reveals the changes in gut microbiota to stimulate aromatic amino acid metabolism in children with allergic rhinitis and constipation
GM dysbiosis in ARFC children activates AAA metabolism, generating neuroactive and pro-inflammatory metabolites that may exacerbate allergic and gastrointestinal symptoms. These findings highlight microbial-metabolite axes as therapeutic targets. Study limitations include cohort size and lack of disease-specific controls, necessitating validation in expanded cohorts.
Authors
- Haiying Liu (ORCID: https://orcid.org/0000-0001-8351-2017)
- Xiaoli Li (ORCID: https://orcid.org/0000-0001-8106-2358)
- Chunyan Wang (ORCID: https://orcid.org/0000-0002-1617-0931)
- Hui Wu (ORCID: https://orcid.org/0000-0002-1757-9990)
- Congfu Huang (ORCID: https://orcid.org/0000-0002-3034-4459)
- Wei Kong
Institutions
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Fourth People's Hospital of Shenzhen (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/falgy.2025.1562832
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61