Molecular interactions of Toxoplasma gondii dense granule 23 (GRA23) with host proteins PEX3 and TRAP1
The interaction between GRA23 and PEX3 suggests potential parasite modulation of peroxisomal functions, while its association with TRAP1 indicates possible exploitation of host chaperone mechanisms. This study provides the first evidence that GRA23 interacts with host proteins implicated in key cellular functions, offering novel insights into <i>T. gondii</i> pathogenesis and potential therapeutic targets for toxoplasmosis treatment.
Authors
- Min Sun (ORCID: https://orcid.org/0000-0002-8528-0050)
- S Li (ORCID: https://orcid.org/0000-0003-0014-5077)
- Muhammad Zahoor Khan (ORCID: https://orcid.org/0000-0001-5890-2996)
- Xuewei Fan
- Nan Zhang (ORCID: https://orcid.org/0009-0004-3415-4072)
- Jianhua Fu (ORCID: https://orcid.org/0000-0001-7885-2498)
- Xin Jiang (ORCID: https://orcid.org/0000-0002-2798-4156)
- Xichen Zhang
- Xiao-Xiao Ma (ORCID: https://orcid.org/0000-0002-9279-2783)
Institutions
- Jilin University (CN)
- Liaocheng University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fvets.2025.1585261
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jilin University
- Natural Science Foundation of Heilongjiang Province