CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer
This study suggests that CS-6 may exert its anti-tumor effects in CRC by inducing autophagy defects, resulting in p62 accumulation and DNA damage <i>in vitro</i> and <i>in vivo</i>.
Authors
- Yinyan Gong (ORCID: https://orcid.org/0000-0002-1461-8077)
- Chiu-Fai Kuok (ORCID: https://orcid.org/0000-0002-5244-8291)
- Qingling Jiang (ORCID: https://orcid.org/0000-0001-7773-393X)
- Xuehui Cui
- Naiyu Zhang (ORCID: https://orcid.org/0000-0002-3330-9923)
- Sixue Bi
- Qi Qi (ORCID: https://orcid.org/0000-0003-4460-0713)
- Menghan Dong
- Liushuyue Wang
- Xiaofei Feng (ORCID: https://orcid.org/0000-0003-1322-4102)
Institutions
- Shandong University of Aeronautics (CN)
- Ludong University (CN)
- Southwest Medical University (CN)
- Macao Polytechnic University (MO)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fphar.2025.1568339
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Binzhou Medical University
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China