Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis
Differences in inflammation among various intestinal segments in HAEC may be linked to ACH secreted by tuft cells. Drugs targeting tuft cells have the potential to become important components of HAEC treatment in the future.
Authors
- Zhongjie Guo (ORCID: https://orcid.org/0000-0001-5043-1560)
- Ruixuan Li (ORCID: https://orcid.org/0000-0002-7791-5511)
- Zhaolei Zheng (ORCID: https://orcid.org/0000-0003-2905-0549)
- Jie Zhou (ORCID: https://orcid.org/0000-0002-4884-6721)
- Xuechao Zhang (ORCID: https://orcid.org/0009-0006-9042-2478)
- Rui Dong (ORCID: https://orcid.org/0000-0002-9118-3636)
- Y. Chen (ORCID: https://orcid.org/0009-0007-5955-7929)
- Lin Lin (ORCID: https://orcid.org/0000-0001-5902-366X)
- Jianxin Chen (ORCID: https://orcid.org/0000-0002-1064-8439)
- Zhe Wang (ORCID: https://orcid.org/0000-0003-4102-1353)
- Yang Wang (ORCID: https://orcid.org/0000-0001-8055-9522)
- Ming Zhong (ORCID: https://orcid.org/0000-0002-1869-2901)
- Feng Chen (ORCID: https://orcid.org/0000-0003-0188-6256)
- Huifang Lin
- Zhiyong Shen (ORCID: https://orcid.org/0000-0002-6155-4598)
- Shiwei He (ORCID: https://orcid.org/0000-0002-1590-0656)
- Cheng Xie (ORCID: https://orcid.org/0000-0001-9833-7784)
- Changliang Lai
Institutions
- Fujian Medical University (CN)
- Children's Hospital of Fudan University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1559966
- Citations
- 5
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 10.03