Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients
The docetaxel TDM provides a reliable basis for monitoring chemotherapy adverse reactions, with high AUC significantly associated with certain adverse reactions. Future studies are expected to include more patients and conduct multi-center trials to obtain a suitable AUC range for Chinese patients, which will guide the determination of clinical chemotherapy doses and reduce the occurrence of adverse reactions.
Authors
- Yongzhe Tang
- Shengying Qin (ORCID: https://orcid.org/0000-0002-8458-5960)
- Jin Zhang (ORCID: https://orcid.org/0000-0001-7241-0760)
- Xiaoqing Zhang (ORCID: https://orcid.org/0000-0002-0052-1629)
- Jie Wang (ORCID: https://orcid.org/0000-0002-5602-0487)
- Yamin Liu (ORCID: https://orcid.org/0000-0003-0031-7799)
- Junwei Fan (ORCID: https://orcid.org/0000-0001-8214-2974)
- Cong Huai (ORCID: https://orcid.org/0000-0002-5946-3179)
- W. X. Ding (ORCID: https://orcid.org/0009-0004-6707-8635)
Institutions
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fphar.2025.1563506
- Citations
- 2
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 2.09