Kaurenoic acid is a potent inhibitor of SARS-CoV-2 RNA synthesis, virion assembly, and release in vitro
In conclusion, KA emerges as an inhibitor of SARS-CoV-2 proteases and, consequently, its replication cycle. It could be a good candidate for further investigation in clinical assays against SARS-CoV-2 infection.
Authors
- Carlos Henrique Gomes Martins (ORCID: https://orcid.org/0000-0001-8634-6878)
- Rodrigo Cássio Sola Veneziani (ORCID: https://orcid.org/0000-0001-7057-9706)
- Natasha Marques Cassani (ORCID: https://orcid.org/0000-0001-9654-0957)
- Gustavo Lima Ribeiro (ORCID: https://orcid.org/0000-0002-8779-176X)
- Mark Harris (ORCID: https://orcid.org/0000-0002-9821-1003)
- Nilson Nicolau-Júnior (ORCID: https://orcid.org/0000-0002-7148-5813)
- Igor Andrade Santos (ORCID: https://orcid.org/0000-0001-7750-4045)
- Ana Carolina Gomes Jardim (ORCID: https://orcid.org/0000-0002-6348-7923)
- Victória Riquena Grosche (ORCID: https://orcid.org/0000-0001-7313-1261)
- Jairo Kenupp Bastos
- Andres Merits
Institutions
- University of Leeds (GB)
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Universidade de Franca (BR)
- Exact Sciences (United States) (US)
- University of Tartu (EE)
- Universidade Federal de Uberlândia (BR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1540934
- Citations
- 1
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81