Prolonged effect of antibiotic therapy on the gut microbiota composition, functionality, and antibiotic resistance genes’ profiles in healthy stool donors
These findings highlight the unpredictable and complex recovery of gut microbiota post-antibiotics. Individualized suspension periods in donor programs, guided by metagenomic analyses, are recommended to optimize FMT outcomes in various indications by considering antibiotic spectrum, duration, and host-specific factors.
Authors
- Perttu Arkkila (ORCID: https://orcid.org/0000-0003-2194-0424)
- Sepideh Pakpour (ORCID: https://orcid.org/0000-0003-3615-1858)
- Dina Kao (ORCID: https://orcid.org/0000-0002-6096-0586)
- Reetta Satokari (ORCID: https://orcid.org/0000-0002-4258-3414)
- Ramin Karimianghadim
- Sam Yeo (ORCID: https://orcid.org/0009-0004-2994-7166)
Institutions
- University of Helsinki (FI)
- University of British Columbia (CA)
- University of Alberta (CA)
- Helsinki University Hospital (FI)
- University of British Columbia, Okanagan Campus (CA)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1589704
- Citations
- 7
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 9.77
Funders
- University of Alberta
- Natural Sciences and Engineering Research Council of Canada